Pharmacology Case Study Example | Topics and Well Written Essays - 1250 words

Pharmacology - Case Study Example A study by Peng et al. (2004) on Pharmacokinetics and Pharmacodynamics of Imatinib in a Phase I Trial with Chronic Myeloid Leukemia Patients, found confirmed the findings of Reckmann et al. (2002) that the drug is absorbed immediately it is administered orally. Further, when they compared imatinib with AUC0-24 hours at steady-state and on day 1, there was a 1.5- to 3-fold drug accumulation after the dose is repeated once a day. Killock (2014) has found that after administration of 350 mg of imatinib at a normal state, the mean plasma trough concentration records at 570 ng/mL and above (about 1 _mol/L). This plasma concentration is more than the 50% inhibitory concentration that successfully inhibits proliferation of BCR-Abl–positive leukemic cells gotten from CML patients (Mitzuta et al. 2013). With imatinib, the relationship between the white blood cells reduction and PK parameters at normal circumstances indicate that the initial imatinib’s hematologic response depend s highly on the dose administered to the CML patient and in this case, a dose higher than 400mg is needed in order to have an optimum effect on white blood cells reduction (Al Ali et al. 2002). From the above information, it is clear that the action of imatinib is therefore different and advanced as compared to the older therapies whose pharmacodynamics and pharmacokinetics are different and present chances of many side effects that in most cases lead to discontinuation of medication therapy.